25/04 - 20:00
| 2015/12/06 | Columbus Crew |  | 1-2 |  | Portland Timbers |
| 1st Leg | 2nd Leg | |||||||
|---|---|---|---|---|---|---|---|---|
| (2-0) |  | 0-0 | 2-0 | ||||
 | (3-3) |  | 2-1 | 1-2 (2 pens-4) |
| 1st Leg | 2nd Leg | |||||||
|---|---|---|---|---|---|---|---|---|
 | (0-2) |  | 0-1 | 0-1 | ||||
 | (3-4) | | 2-1 | 1-3 a.e.t. |
| 2015/10/28 | DC United | | 2-1 |  | NE Revolution | ||||
| 2015/10/29 | Seattle Sounders | | 3-2 |  | LA Galaxy | ||||
| Montreal Impact | | 3-0 |  | Toronto FC | |||||
| 2015/10/30 | Portland Timbers | | 2-2 (7-6 pens) |  | Sporting KC |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | NY Red Bulls | 34 | 62 | 43 | 60 |
| 2 | | Columbus Crew | 34 | 58 | 53 | 53 |
| 3 | | Montreal Impact | 34 | 48 | 44 | 51 |
| 4 | | DC United | 34 | 43 | 45 | 51 |
| 5 | | NE Revolution | 34 | 48 | 47 | 50 |
| 6 | | Toronto FC | 34 | 58 | 58 | 49 |
| 7 |  | Orlando City | 34 | 46 | 56 | 44 |
| 8 |  | New York City FC | 34 | 49 | 58 | 37 |
| 9 |  | Philadelphia Union | 34 | 42 | 55 | 37 |
| 10 |  | Chicago Fire | 34 | 43 | 58 | 30 |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | FC Dallas | 34 | 52 | 39 | 60 |
| 2 | | Vancouver Whitecaps | 34 | 45 | 36 | 53 |
| 3 | | Portland Timbers | 34 | 41 | 39 | 53 |
| 4 | | Seattle Sounders | 34 | 44 | 36 | 51 |
| 5 | | LA Galaxy | 34 | 56 | 46 | 51 |
| 6 | | Sporting KC | 34 | 48 | 45 | 51 |
| 7 |  | SJ Earthquakes | 34 | 41 | 39 | 47 |
| 8 |  | Houston Dynamo | 34 | 42 | 49 | 42 |
| 9 |  | Real Salt Lake | 34 | 38 | 48 | 41 |
| 10 |  | Colorado Rapids | 34 | 33 | 43 | 37 |
 | |
| |
|
| 2 |
|
Sebastian Giovinco Toronto FC | 22 G |
| 3 |
|
Robbie Keane LA Galaxy | 20 G |
| 4 |
|
Fanendo Adi Portland Timbers | 18 G |
| 4 |
|
Bradley Wright-Phillips NY Red Bulls | 18 G |
